Sedation for local anaesthesia. Comparison of intravenous midazolam and diazepam

Comparison of diazepam and midazolam for sedation during local anaesthesia for bronchoscopy.

Bronchoscopy was performed in 76 outpatients using local anaesthesia plus diazepam 0.2 mg kg-1 i.v. or midazolam 0.05 or 0.1 mg kg-1 i.v. Patient co-operation and ease of bronchoscopy were good in all patients. Two hours after injection, 67% (diazepam 0.2 mg kg-1), 36% (midazolam 0.05 mg kg-1) and 75% (midazolam 0.1 mg kg-1) of the patients failed to recall the insertion of the bronchoscope. Si...

Intravenous sedation for upper gastrointestinal endoscopy: diazepam versus midazolam.

Comparison of the i.v. administration of midazolam and diazepam as sedation during spinal anaesthesia.

Midazolam hydrochloride and diazepam in emulsion were compared as i.v. sedatives for spinal anaesthesia. Mean doses of midazolam 12 mg and diazepam 27 mg were required to induce sleep and provide good or adequate sedation throughout surgery of approximately 1 h duration. Neither drug caused loss of the airway or significant cardiorespiratory changes. The frequency of drowsiness after operation ...

Diazepam and midazolam for sedation during bronchoscopy.

Sir,—It is regretted that the interesting paper by Korttila and Tarkkanen (1985) does not state which preparation of diazepam they used. The early relative potency studies of midazolam and diazepam were undertaken with the organic solvent preparation, Valium. A review (Dundee et al., 1984) of these puts the relative potency of the two drugs at about 1.5:2.1:1. However, if Korttila and Tarkkanen...

Sedation during spinal anaesthesia: comparison of propofol and midazolam.

Propofol and midazolam were compared in 40 patients undergoing orthopaedic surgery under spinal anaesthesia. An infusion of either 1% propofol or 0.1% midazolam was given at a rate adjusted to maintain a similar level of sedation. The mean time to reach this required level was similar in both groups. Quality and ease of control of sedation were good in all patients. A mean infusion rate of 3.63...